📖 Prevalence of type 2 Diabetes Mellitus has been increasing significantly in all countries. It is widely recognized that the most serious problem in DM arises from the insidiously developing vascular complications.This cross-sectional study, aimed to determine the level of serum phospholipids in Sudanese patients suffering from diabetes mellitus type 2.Fifty samples were collected from Almotkamil centre. The study included both sexe, 25 males (aged 45-70years), whereas, 25 were females (aged 45-68years). Venous blood (2.5 ml) were taken from each patient in lithium heparin container; serum was obtained in plain container, and the samples were analyzed for serum phospholipids levels using spectrophotometer. Statistical analysis of the results showed that, the means of serum phospholipids in diabetic patients was higher 275.8mg/dl, p.value 0.000) compared to the reference value of phospholipids levels.From the result of the present study, it is concluded that;plasma phospholipids levels represent a marker for accelerated atherosclerosis, particularly in type 2 diabetic patients. Thus, measurement of plasma phospholipids could be useful for stratification of cardiovascular risk.