📕 These study explores on the relationship between Polymorphisms of glutathione-S-transferase M1, T1 which is a family of cytosolic enzymes involved in the detoxification of various exogenous as well as endogenous reactive species and the risk of prostate cancer in the Iraqi patients.The present study was included 35 Iraqi men who were diagnosed as prostate cancer patients. the age of the patient ranged from 40 to 86 years. and 25 Apparently healthy men, blood sample were collected Frome the Gazhi Alhariri hospital(in Baghdad),during the period from November, 2012 to may,2013.blood group, Age, family history, smoking were analyzed to observe any relationship between theme and prostate cancer to taken in account as risk factors.